Description
Semaglutid 2 MG Driada Medical Description
Semaglutid 2 MG Driada Medical is a glucagon-like peptide-1 (GLP-1)-Receptor agonist, which is produced by recombinant DNA biotechnology. Semaglutid is a GLP-1 analogue with 94 % Homology to human GLP-1. Semaglutide acts as a GLP-1R agonist, The selectively binds to GLP-1R and activates it. GLP-1R serves as the goal for native GLP-1.
Mechanism of action of Semaglutid 2 mg Driada Medical
GLP-1 is a physiological hormone with several effects on glucose regulation and appetite as well as on the cardiovascular system. The effect on the glucose concentration and the appetite is specifically conveyed by GLP-1R, that is located in the pancreas and in the brain. Pharmacological concentrations of Semaglutid reduce blood sugar concentration and body weight by combining the effects described below. GLP-1R are also in certain areas of the heart, The blood vessels, of the immune system and the kidneys available, Where your activation can have cardiovascular and microcircular effects.
In contrast to native GLP-1, the extended half-life of Semaglutid is about 1 Week. You can use it once a week. The bond with albumin is the main mechanism for the long -term effect of Semaglutid, which leads to a reduced excretion over the kidneys and protects against metabolic breakdown. In addition, Semaglutid is stable against the split by the enzyme dipeptidylpeptidase-1.
Semaglutid lowers the blood sugar level by glucose -dependent stimulation of insulin secretion and suppression of glucagon secretion. In this way, insulin secretion is stimulated when the blood sugar concentration increases and the glucagons secretion is suppressed. The mechanism for reducing the glycemic mirror also includes a slight delay in gastric emptying in the early postprandial phase. During hypoglycaemia, Semaglutid reduces insulin secretion, but not the glucagon secretion.
Semaglutid usage purpose
Semaglutid reduces the total body weight and the fat tissue by reducing energy intake. This mechanism includes a general decrease in the appetite, including an increase in satiety signals and a decrease in hunger signals, as well as improved control of food intake and a reduction of the cravings. The insulin resistance is also reduced, possibly due to weight loss. In addition, Semaglutid reduces the preference for high -fat meals. It was shown in animal studies, that Semaglutid is absorbed by certain areas of the brain and increased important saturation signals and important hunger signals weakened. Due to the effect on isolated areas of the brain tissue, Semaglutide activates neurons, that are associated with saturation, and suppresses neurons, that are associated with hunger.
In clinical studies, Semaglutid had a positive effect on the plasmalipides, lowered systolic blood pressure and reduced inflammation.
In animal experiments, Semaglutid inhibits the development of arteriosclerosis, by preventing the further development of aortic plaques and reducing inflammation in the plaques.
Compared to placebo, Semaglutid reduced calorie intake during three daily meals by 18–35 %.
Compared to placebo, Semaglutid reduced the sober triglyceride and the VLDL cholesterol 12 % or. 21 %. Postprandial climbs of the triglyceride and the VLDL cholesterol in response to a high-fat meal were more than 40 % reduced.
Semaglutid lowered the glucose mirror after the first dose.
How to use the service
Semaglutid-dose von 0.5 mg and 1 MG ensure sufficient exposure to the drug in the body weight area of 40 bis 198 kg.
The initial dose is in the first 0.25 weeks 4 mg once a week. This gives your body the opportunity, get used to the medicine.
Weekly 5 you can open the dose once a week 0.5 increase mg.
The maximum dose is 2 mg once a week.
Create an injection once a week, Every week on the same day.
Positive effects
- Improves the function of the β cells of the pancreas.
- Reduces the glucagon concentration
- Lowers high blood sugar levels
- Acceptance of insulin resistance
- A significant reduction in the middle systolic blood pressure
- Weight loss mainly due to loss of adipose tissue
Side effects
- Diarrhea
- constipation
- nausea
- Vomit
- Diarrhea
- Abdominal pain
- constipation
- heartburn
- Bump off
Warnings
Some side effects can be serious. If you occur with you one of these symptoms, Call your doctor immediately or have an emergency medical treatment:
- Persistent pain, that start at the top left or in the middle of the stomach, but can spread to the back, with or without a breakdown; itching; Swelling of the eyes, of the face, of the mouth, the tongue or throat; Or difficulty breathing or swallowing; reduced urination; or swelling of the legs, ankle, •
- Or visual disturbances of the feet, Fainting or dizziness
- Pain in the upper abdomen; Yellow color of the skin or eyes; Fever; or clay -colored chair, quick heartbeat
How to prepare a solution with Semaglutid 2 mg Drugda Medical vor
To create an injection solution, Take a syringe, which already contains a dilute, and inject them into a fold bottle with a lyophilized powder. Tilt the pitch bottle like this, that the needle touches the pitch bottle wall. Avoid it, To inject the dilution aid directly into the lyophilized powder. The solvent should slowly flow down on the bottle wall (Don’t fill everything at once and take your time).
As soon as the entire dilution has been placed in the peptide bottle, Mix carefully (But don’t stir or shake the bottle), Until the lyophilized powder has dissolved and you get a clear liquid. Now the drug is ready for use.
Never mix a peptide with another in the same syringe. This exists the danger, that fragile peptide molecules are destroyed.
Application for Semaglutid 2 mg Driada Medical
Depending on the personal preference, the injection can be subcutaneously or intramuscularly.
Injections
- Injections can be done subcutaneously and intramuscularly with an insulin syringe.
- Disinfect the rubber cap of the medicine and the injection site with alcohol.
- Draw the medication into a syringe and inject it slowly.
Steroid medication profile
- Half-life: 165 Hours
- Frequency of intake – once a week
Contraindications
- Limit alcohol consumption while taking this drug, Since this can increase the risk of hypoglycaemia.
How to store?
- At a temperature of no more than 30 ° C or at a temperature of 2 °C to 8 °C (in the fridge) 56 Store for days.
- Do not freeze
- Do not use Semaglutid, When it is frozen
- Keep away from children
- Do not use after the expiry date
